陈楠楠 教授、博士生导师

E-mail: nannanchen27@seu.edu.cn

办公地点：东南大学江北校区汇川楼B401

个人简介：

陈楠楠，东南大学yh533388银河教授、博士生导师。本科毕业于浙江大学生命科学学院，博士毕业于中国科学院生物物理研究所；之后于美国布兰迪斯大学(Brandeis University)进行博士后研究，2023年10月加入东南大学yh533388银河。

研究方向：

神经传递是神经元之间信息交流的核心机制；传统观点认为神经传递是单一且稳定的，而神经共传递(co-transmission)和神经递质转换(neurotransmitter switch)挑战了这一观点；神经传递的异常与多种神经系统疾病相关。本课题组以果蝇为主要研究模型，结合临床数据，运用基因编辑、活体成像、行为检测等多种技术手段，深入探讨神经共传递与神经递质转换的基本机制，并探索神经传递异常在神经系统疾病中的致病机理及其潜在治疗策略。

代表性论文：

1.    Ivy Chi Wai Chan*, Nannan Chen*, John Hernandez*, Hagar Meltzer*, Annie Park*, Aaron Stahl*. Future avenues in Drosophila mushroom body research. Learning & Memory 2024 (Co-first author, review).

2.    Nannan Chen*, Yunpeng Zhang*, Emmanuel J. Rivera-Rodriguez*, Albert D. Yu, Michael Hobin, Michael Rosbash and Leslie C. Griffith. “Widespread posttranscriptional regulation of cotransmission”.Science Advances 2023 (Co-first author)

3.    Nannan Chen, Yunpeng Zhang, Mohamed Adel, Elena A. Kuklin, Martha L. Reed, Jacob D. Mardovin, Baskar Bakthavachalu, K. VijayRaghavan, Mani Ramaswami and Leslie C. Griffith. “Local translation provides the asymmetric distribution of CaMKII required for associative memory formation”, Current Biology 2022

4.    Mohamed Adel, Nannan Chen, Yunpeng Zhang, Martha L. Reed, Christina Quasney and Leslie C. Griffith. “Pairing-dependent plasticity in a dissected fly brain is input-specific and requires synaptic CaMKII enrichment and nighttime sleep”, Journal of Neuroscience 2022

5.    Mingmin Zhou*, Nannan Chen*, Jingsong Tian, Jianzhi Zeng, Yunpeng Zhang, Xiaofan Zhang, Jing Guo, Jinghan Sun, Yulong Li, Aike Guo, Yan Li. “Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning”, PNAS2019. (Co-first author)

6.    Nannan Chen, Aike Guo and Yan Li. “Aging accelerates memory extinction and impairs memory restoration in Drosophila”, Biochemical and Biophysical Research Communications 2015.

7.    Yan Yin, Nannan Chen., Shixing Zhang and Aike Guo. “Choice strategies in Drosophila are based on competition between olfactory memories”, European Journal of Neuroscience 2009.