赵旭杰 副研究员
联系方式：19821385855
个人简介：
本科毕业于河南大学，硕士毕业于上海交通大学医学院，博士毕业于美国田纳西大学健康学中心/圣裘德儿童研究医院（联合培养），随后于美国圣裘德儿童研究医院作博士后研究。2023年8月入职东南大学yh533388银河，担任副研究员。
研究方向：
遗传性变异和获得性变异是导致癌症发生的两种重要因素，本课题组主要研究癌症遗传性变异和获得性变异如何影响转录调控的分子机制。在遗传学，表观遗传学，翻译后修饰，药物基因组学等多层面，深入解析癌症遗传性和发生、发展的分子生物学基础，以及化疗耐药的分子机制，并为如何克服化疗耐药提供了新的靶点；为难治性癌症提供新的靶向治疗靶点及相应的治疗方案，并进行临床前药效验证。
代表性论文：
1. Xujie Zhao*, Ping Wang*, Jonathan D. Diedrich, Jingliao Zhang, Wentao Yang, Kelly Barnett, Beisi Xu, Zhenhua Li, Allen Eng Juh Yeoh, Marina Konopleva, Chia-Lin Wei, Ching-Hon Pui, Daniel Savic, Jun J Yang. Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia. Nature Communications. 2022 Sep 14;13(1):5401. (PMID: 36104354; Top 50 selected papers)
2. Shaela Wright*, Xujie Zhao*, Wojciech Rosikiewicz, Shelby Mryncza, Judith Hyle, Wenjie Qi, Zhenling Liu, Siqi Yi, Yong Cheng, Beisi Xu & Chunliang Li. Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens. Nature Communications 14, 7464 (2023). (PMID: 38016946)
3. Xujie Zhao*, Maoxiang Qian*, Charnise Goodings*, Wentao Yang, Yang Zhang, Wenjian Yang, Ping Wang, Beisi Xu, Cheng Tian, Ching-Hon Pui, Stephen P. Hunger, Elizabeth A. Raetz, Meenakshi Devidas, Mary V. Relling, Mignon L. Loh, Daniel Savic, Chunliang Li, Jun J Yang. Molecular mechanisms of ARID5B-mediated genetic susceptibility to acute lymphoblastic leukemia. J Natl Cancer Inst. 2022 Sep; 9(114):1287-1295. (PMID:35575404)
4. Siyang Wang*, Yabin Liu*, Xujie Zhao*, Xiaoling Wang, Jiacheng Lou, Peng Jin, Yi Zhang, Jinyi Yu, Kankan Wang. RUNX1::ETO and CBFβ::MYH11 converge on aberrant activation of BCAT1 to confer a therapeutic vulnerability in core-binding factor-acute myeloid leukaemia. B J Haem. 2024 Aug; 205 (2):552. (PMID: 38802066)
5. Heng Xu*, Xujie Zhao*, Deepa Bhojwani, E Shuyu, Charnise Goodings, Hui Zhang, Nita L Seibel, Wentao Yang, William L Carroll, William E Evans, Jun J Yang. ARID5B influences anti-metabolite drug sensitivity and prognosis of acute lymphoblastic leukemia. Clinical Cancer Research 26(1):256-264, 2020. (PMID: 31573954)
6. Charnise Goodings*, Xujie Zhao*, Shannon McKinney-Freeman, Hui Zhang, Jun J Yang. ARID5B influences B cell development and function in mouse. Haematologica. 2023; 108 (2). (PMID: 35924577)
